Fungi are major pathogens of humans, animals, and plants. Controlling fungal pathogens is of major importance for both human health and food security. There are very few antifungal agents available, and the same ones are frequently used in both human health and agriculture, which has led to the rapid emergence of resistant fungal pathogens. This talk will give an overview of current knowledge on how agricultural azole use is driving off-target resistance in human pathogens, with a case-study drawing on emerging data from Vietnam, where unprecedented rates of resistance have recently been described in both Aspergillus flavus and fumigatus.