Infectious diseases are a leading cause of mortality worldwide. Additionally, the emergence of multi drug resistant bacterial strains due to the widespread and inappropriate use of drugs to treat infections poses a big threat to human health. To combat the rise in antibiotic resistance, there is a need for novel strategies to combat infections such as the development of novel vaccines. Salmonella Typhimurium is a leading cause of gastroenteritis worldwide. In immunocompromised individuals Salmonella Typhimurium can cause an invasive disease known as invasive Non-typhoidal Salmonella (iNTS). The vaccines currently available to treat Salmonella infections are comprised of live attenuated organisms. These vaccines can cause an infection in immunocompromised individuals and are only protective against S. Typhi and no other Salmonella infections. In this work we investigated the immunogenicity and protective efficacy of putative vaccines against Salmonella enterica Typhimurium. These vaccines elicited high antibody titres and provided partial protection against salmonellosis.